Synthesis of 14C-labelled 1,2-bis (3,5-dioxopiperazin-1-yl) ethane (ICRF154)

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Synthesis of 14C-labelled 1,2-bis (3,5-dioxopiperazin-1-yl) ethane (ICRF154)

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- Synthesis of 14C-labelled 1,2-bis (3,5-dioxopiperazin-1-yl) ethane (ICRF154)
- Nuclear Techniques Vol. 11, Issue 1, (1988)
- 作者机构：
  
  天津医药科学研究所
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：1988-01
- 稿件说明：
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Guolin Yang. Synthesis of 14C-labelled 1,2-bis (3,5-dioxopiperazin-1-yl) ethane (ICRF154)[J]. Nuclear techniques, 1988, 11(1): 49-50.
DOI：

Guolin Yang. Synthesis of 14C-labelled 1,2-bis (3,5-dioxopiperazin-1-yl) ethane (ICRF154)[J]. Nuclear techniques, 1988, 11(1): 49-50. DOI：

摘要

Hellman及其同事们在ICRF实验室进行药物筛选，发现ICRF154口服对实验肿瘤L

1210

和肉瘤S

180

意外有效。在临床试用中既不活泼也没毒性，认为吸收差与药物不溶解有关。

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