Studies on preparation of multiple tritiated steroids hormones

Linxiang Yin; Guozhong Tang; Deliang Chen; Guangming Pan; Xialing Zhao

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Studies on preparation of multiple tritiated steroids hormones

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- Studies on preparation of multiple tritiated steroids hormones
- Nuclear Techniques Vol. 11, Issue 1, (1988)
- 作者机构：
  
  中国科学院上海原子核研究所
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：1988-01
- 稿件说明：
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Linxiang Yin, Guozhong Tang, Deliang Chen, et al. Studies on preparation of multiple tritiated steroids hormones[J]. Nuclear techniques, 1988, 11(1): 39-40.
DOI：

Linxiang Yin, Guozhong Tang, Deliang Chen, et al. Studies on preparation of multiple tritiated steroids hormones[J]. Nuclear techniques, 1988, 11(1): 39-40. DOI：

摘要

本文对四种人体甾族生殖激素进行了放射性多位氚标记的研制。

1。 [1，2，6，7-

H]孕酮，[1，2，6，7-

H]睾丸酮及[1，2，6，7-

H]皮质醇的合成。前体

△-孕酮，

△-睾丸酮及

△-皮质醇分别溶于二氧六环，用催化剂10%钯碳经催化加氚后，除去催化剂及不稳氚，经硅胶纸层析分离纯化，放射性产物的化学量与浓度用分光光度计在λ

max

为241nm波长时测定，其平均摩尔消光系数分别为16850，14550及15400。用液闪测得，氚标记物的总比活度分别为3.56、3.04、3.36TBq/mmol。用放射性硅胶纸层析及高效液相色谱法测得氚标记物放化纯度均大于98%。为保证分子中1.2及6.7位的双键被氚化，必须严格控制反应条件。

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