The synthesis, labelling and animal test of new brain imaging agent <sup>131</sup>I-IMP

Meizhen Sun; Qiang Huang; Meichu Luo; Landi Li; Meizhen Zhang; Binyuan Shen; Maosong Jiang

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The synthesis, labelling and animal test of new brain imaging agent ¹³¹I-IMP

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- The synthesis, labelling and animal test of new brain imaging agent ¹³¹I-IMP
- Nuclear Techniques Vol. 10, Issue 5, (1987)
- 作者机构：
  
  1.上海医科大学放射医学研究所
  2.华东医院
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Received：12 September 1986，
  
  Published：1987-05
- 稿件说明：
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Meizhen Sun, Qiang Huang, Meichu Luo, et al. The synthesis, labelling and animal test of new brain imaging agent ¹³¹I-IMP[J]. Nuclear techniques, 1987, 10(5): 48-51,64.
DOI：

Meizhen Sun, Qiang Huang, Meichu Luo, et al. The synthesis, labelling and animal test of new brain imaging agent ¹³¹I-IMP[J]. Nuclear techniques, 1987, 10(5): 48-51,64. DOI：

摘要

作者对新型脑显像剂——N－异丙基对碘安菲他明进行了合成，研究了碘标记（

131

I-IMP）条件，并观察动物体内分布特点。结果表明：在Cu（I）催化下150℃

30min

131

I标记率

96%，放化纯度达98%，放射活性回收率为90%；大鼠体内分布：脑／血比值：

131

I-IMP在5min和60min分别为6.7和13.2。兔体内分布亦获同样结果。

Abstract

This paper reports a new brain imaging agent-

131

I-IMP (

131

I-N-isopropyl-p-iodoamp-hetamine) synthesized from phenylacetic acid and labelled with

131

I in the hydrothermal melting method. The optimum reaction was kept in 150℃ for 30 min and Cu (Ⅱ) was used as a catalyst. The labelling efficiency

radiochemistry purity and radioactive recovery of

131

I-IMP were 96%

98% and 90% respectively.

The brain-blood ratio was 6.7 at 5 min and 13.2 at 60 min on rat fallowing IIMP intravenous administration.

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references

蒋茂松等，中华核医学杂志， 2 , 121 ( 1984 )。

B. L. Holman et al. , J. Nucl. Med. , 25 , 25 ( 1984 ).

J. T. Plati et al. , J. Amer. Chem. Soc. , 65 , 1273 ( 1943 ).

L. Carlsen et al. , Eur. J. Nucl. Med. , 7 , 280 ( 1982 ).

S. C. Frank et al. , J. Org. Chem. , 9 , 529 ( 1944 ).

D. E. Kuhl et al. , J. Nucl. Med. , 23 , 196 ( 1982 ).

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The synthesis, labelling and animal test of new brain imaging agent 131I-IMP

DOI：

摘要

Abstract

关键词

Keywords

references

The synthesis, labelling and animal test of new brain imaging agent ¹³¹I-IMP