The preparation of radioiodine labelled amiodarone

Jialing Gong; Ping Yan; Yanru Li

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The preparation of radioiodine labelled amiodarone

更新时间：2022-08-16

- The preparation of radioiodine labelled amiodarone
- Nuclear Techniques Vol. 10, Issue 5, (1987)
- 作者机构：
  
  上海医科大学药学院
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Received：14 August 1986，
  
  Published：1987-05
- 稿件说明：
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Jialing Gong, Ping Yan, Yanru Li. The preparation of radioiodine labelled amiodarone[J]. Nuclear techniques, 1987, 10(5): 52-54,58,64.
DOI：

Jialing Gong, Ping Yan, Yanru Li. The preparation of radioiodine labelled amiodarone[J]. Nuclear techniques, 1987, 10(5): 52-54,58,64. DOI：

摘要

乙胺碘呋酮是目前广泛应用的广谱抗心律失常药，随着临床应用的增多，一些副作用如使甲状腺功能紊乱及肺损害等

亦随之显现出来。对其进一步作临床药理研究，甚为必要。同位素示踪技术则是研究手段之一。

Abstract

Radioiodine labelled amiodarone can be conveniently obtained in the presence of copper (Ⅱ) and excess reductant by hydrothermal method

at 100℃ for 1 hour and separated by TLC. Labelling efficiency is over 95%. Radiochemical purity is over 95%. The hydrothermal exchange method is a simple monocompartment isotope exchange reaction in homogeneous system and obeys the exponential law.

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Keywords

references

Douglas P. Zipes and Paul J. Troup , Am. J. Cardiol. , 41 , 6 , 1005 ( 1978 ).

游凯等，中国临床药理学杂志 , 1 , 1 , 52 ( 1985 )。

Jecques Brockhuysen et al. , Arch. Int. Pharmacodyn. Ther. , 177 , 2 , 340 ( 1969 ).

Francoise Savoie et al. , J. Chromatogr. , 261 , 2 , 305 ( 1983 ).

John Mertens et al. , J. Label. Compounds and Radiopharmaceuticals , 22 , 1 , 89 ( 1985 ).

Cohen Theodore et al. , Tetrahedron Letters , 40 , 3555 ( 1974 ).

J. Mertens et al. , Fast quantitative labelling of p-I-123-N-isoprophylamphctamine (IMP) in presence of Cu (I) and ascorbic acid, allowing kit-form preparation , Taarbeeklaan, 103, B-1090, Brussels(Belgium) .

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