Synthesis of 14C-niclosamide, 14C-hехаchlогo-Р-хуlеnе and 35S-thiabromfen

Xin Zhang; Zhengguo Zou; Zhengxiu Yang

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Synthesis of ¹⁴C-niclosamide, ¹⁴C-hехаchlогo-Р-хуlеnе and ³⁵S-thiabromfen

更新时间：2022-08-16

- Synthesis of ¹⁴C-niclosamide, ¹⁴C-hехаchlогo-Р-хуlеnе and ³⁵S-thiabromfen
- Nuclear Techniques Vol. 09, Issue 4, (1986)
- 作者机构：
  
  中国科学院上海药物研究所
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：1986-04
- 稿件说明：
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Xin Zhang, Zhengguo Zou, Zhengxiu Yang. Synthesis of ¹⁴C-niclosamide, ¹⁴C-hехаchlогo-Р-хуlеnе and ³⁵S-thiabromfen[J]. Nuclear techniques, 1986, 09(4): 49.
DOI：

Xin Zhang, Zhengguo Zou, Zhengxiu Yang. Synthesis of ¹⁴C-niclosamide, ¹⁴C-hехаchlогo-Р-хуlеnе and ³⁵S-thiabromfen[J]. Nuclear techniques, 1986, 09(4): 49. DOI：

摘要

2－甲氧基－5－氯苯胺与K

CN经Sandmeyer反应制成2二甲氧基－5二氯苯甲腈经水解得5－氯-［1-

C］-水杨酸，后者制成相应的酰氯后与2－氯－4－硝基苯胺反应即得［

C］-氯硝柳胺，总收率38%。对－甲苯胺与K

CN经Sandmeyer反应生成的腈经水解后得［1-

C］-对甲苯甲酸，后者用LiAlH

还原成［1-

C］-对甲苯甲醇，再以SoCl

氯化成相应的氯苄，进一步通氯即得［

C]-六氯对二甲苯，总收率33%。SCl

与

S经低温加热交换生成

SCl

，后者与对氯苯酚生成二氯二羟基二苯硫醚，再进一步与溴反应即得［

S］-2，2'-二烃基-3

3'-二溴代－5

5'-二氯代二苯硫醚，又2名［

S］-硫溴酚，放化总收率15—20%

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