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1.中国原子能科学研究院
2.华北辐射研究所
Published:1986-04
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Mingguang Yi, Lun Xiao, Jue Feng, et al. Synthesis of labelling new chelaiing agent (H-73-10)with tritium and carbon-14[J]. Nuclear techniques, 1986, 09(4): 45-46.
DOI:
Mingguang Yi, Lun Xiao, Jue Feng, et al. Synthesis of labelling new chelaiing agent (H-73-10)with tritium and carbon-14[J]. Nuclear techniques, 1986, 09(4): 45-46. DOI:
新型螯合剂H-73-10是用于促排锕系放射性核素钚、钍和铀。其效果显著优于二十余年居于首位的Ca-DTPA。通过鼠、狗和猴的急性、亚急性毒性以及系统的药理实验,其毒性不高于Ca-DTPA。为了研究此新药在体内分布、代谢途径以及寻找药物的最适剂量,进行了碳-14和氚的标记。此药物的化学结构如下:
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