Label of <sup>99m</sup>Tc-hexakis (t-butylisonitrile) and its metabolism and distribution in rats

Yuzhi Guo; Qinfang Kuang; Bin Lou; Ping Fang; Yan Zhao

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Label of ^99mTc-hexakis (t-butylisonitrile) and its metabolism and distribution in rats

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- Label of ^99mTc-hexakis (t-butylisonitrile) and its metabolism and distribution in rats
- Nuclear Techniques Vol. 09, Issue 4, (1986)
- 作者机构：
  
  江苏省原子医学研究所
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：1986-04
- 稿件说明：
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Yuzhi Guo, Qinfang Kuang, Bin Lou, et al. Label of ^99mTc-hexakis (t-butylisonitrile) and its metabolism and distribution in rats[J]. Nuclear techniques, 1986, 09(4): 36-37.
DOI：

Yuzhi Guo, Qinfang Kuang, Bin Lou, et al. Label of ^99mTc-hexakis (t-butylisonitrile) and its metabolism and distribution in rats[J]. Nuclear techniques, 1986, 09(4): 36-37. DOI：

摘要

本文报道了使用均相配体交换法标记

99m

Tc-特丁基异腈（

99m

Tc-TBI）的方法和步骤。其方法是：将0.5—3.0ml的

99m

Tc-GH溶液与0.2ml的TBI乙醇溶液混合后放入100℃沸水浴中15 -30分钟后置室温冷却即可使用。该法标记方便，标记率和放射化学纯度均大于90%，便于临床推广和使用。

99m

Tc-TBI在大鼠血中清除快，

1/2

为3.7分，

1/2

为63分，给药后30分钟血中放射性仅剩13%，给药后1和2小时的心／血比值分别为62.2和48.7，心／肺比为3.7和4.0，心／肝比值为0.85和0.81。而每克小鼠心肌中的百分吸收值在1、2和4小时时分别为11.1±2.6%、13.1±2.1%和12.8±1.5%。实验所示，

99m

Tc-TBI标记方便、产率高、标记物稳定，它在鼠心肌中浓聚高、时间长、易于临床推广和使用，是一种有发展前途的用Tc标记的心肌显像剂。

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Label of 99mTc-hexakis (t-butylisonitrile) and its metabolism and distribution in rats

DOI：

摘要

Abstract

关键词

Keywords

references

Label of ^99mTc-hexakis (t-butylisonitrile) and its metabolism and distribution in rats