The preparation and biologic studies of <sup>99m</sup>Tc-PHT (a hepatobiliary imaging agent)

Shaoliang Chen; Huiyang Zhao; Xiaoming Yan

您当前的位置：

首页 >

文章列表页 >

The preparation and biologic studies of ^99mTc-PHT (a hepatobiliary imaging agent)

更新时间：2022-08-16

- The preparation and biologic studies of ^99mTc-PHT (a hepatobiliary imaging agent)
- Nuclear Techniques Vol. 09, Issue 3, (1986)
- 作者机构：
  
  1.上海医科大学附属中山医院
  2.中国科学垸上海药物研究所
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Received：09 July 1984，
  
  Published：1986-03
- 稿件说明：
移动端阅览
Shaoliang Chen, Huiyang Zhao, Xiaoming Yan. The preparation and biologic studies of ^99mTc-PHT (a hepatobiliary imaging agent)[J]. Nuclear techniques, 1986, 09(3): 52-54,61.
DOI：

Shaoliang Chen, Huiyang Zhao, Xiaoming Yan. The preparation and biologic studies of ^99mTc-PHT (a hepatobiliary imaging agent)[J]. Nuclear techniques, 1986, 09(3): 52-54,61. DOI：

摘要

1975年R.J.Baker

等已使用

99m

Tc标记的吡哆醛氨基酸类作为肝胆显像剂，但其制备繁复且需高压程序。其后采用亚锡离子作还原剂，已能在常压下进行标记

。1982年Kato-Azuma等将吡哆醛和氨基酸缩合形成的亚胺键（R

C=N-R'）经加压加氢还原为稳定的胺键（R

HC-NHR'）

[5]

。这样形成的化合物更为稳定，易于制备药盒，并免除了药盒中需要大量吡哆醛和氨基酸的缺点及减少了与螯合剂竞争的潜在可能

[6]

。我们参考有关文献

7，8]

在常温常压下成功地制备了吡哆色氨酸（PHT），化学名N-{［（3－羟基-5-羟甲基）-2-甲基-4-吡啶］甲基}-L－色氨酸。本文报道其合成、药盒制备、标记、动物实验和初步试用的结果。

Abstract

A derivative of N-pyridoxylamino acid-N-pyridoxyl-tryptophan (PHT) was synthesized by a new method and the Sn-PHT kit was prepared. The

99m

Tc-complex of this compound was prepared by

stannous chloride reduction of sodium pertechnetate and

heated for 10 minutes in a boiling water bath.

99m

Tc-PHT was excreted into the bile and we can obtain better hepatobiliary image. We also discussed the drawback of this agent.

关键词

Keywords

references

R. J. Baker et al . , J. Nucl. Med. , 16 , 720 ( 1975 ).

R. J. Baker et al . , Int. J. Nucl. Med. Biol. , 4 , 85 ( 1977 ).

Kazuko Kazuko et al . , Eur. J. Nucl. Med. , 6 , 567 ( 1981 ).

M. Kato-Azuma et al . , J. Nucl. Med. , 19 , 397 ( 1978 ).

M. Kato-Azuma et al . , ibid , 23 , 517 ( 1982 ).

陈绍亮节译，国外医学放射医学分册， 4 , 243 ( 1983 )。

D. Heyl . , J. Amer. Chem. Soc. , 70 , 3429 ( 1948 ).

M. Ikawa , Arch. Biochem. Biophys. , 118 , 498 ( 1967 ).

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Clinical evalution of radionuclide phase analysis on the patients with preexcitation syndrome

A study on ^99mTc-SCIDA and ^99mTc-ICIDA as hepatobiliary imaging agents

A new way for preparation of ^99mTc-stannous colloid instant kit

The synthesis, labelling and animal experiment of a regional cerebral blood flow imaging agent ^99mTc-HM-PAO

Studies on ^99mTc-HM-PAO as a regional cerebral blood flow imaging agent

Related Author

Jixian Zhang

Chengmo Zhu

Hui Wang

Huiyang Zhao

Xirui Zhou

Shaoliang Chen

Jingquan Wen

Aina Yuan

Related Institution

Ruijin Hospital, Shanghai Second Medical University

Zhongshan Hospital, Shanghai Medical University

Shanghai Medical University

School of Pharmacy, Shanghai Medical University

AI问答

Address：2019 Jialuo Road, Jiading, Shanghai, China Postal code：201800
Tel：021-39194977 Email：LHB@sinap.ac.cn
Technical support is provided by Beijing Founder electronics co., LTD 沪ICP备05005479号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.
Total Visits：880523 Visits Today：50

⁰

The preparation and biologic studies of 99mTc-PHT (a hepatobiliary imaging agent)

DOI：

摘要

Abstract

关键词

Keywords

references

The preparation and biologic studies of ^99mTc-PHT (a hepatobiliary imaging agent)