The preparation of <sup>211</sup>At-astatine labelled protein and peptides

Liyi Lu; Zhenghao Liu; Zhigang Tang; Cheng Luo; Qunxia Duan; Jimin Zhang; Yanyan Zhang

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The preparation of ²¹¹At-astatine labelled protein and peptides

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- The preparation of ²¹¹At-astatine labelled protein and peptides
- Nuclear Techniques Vol. 09, Issue 3, (1986)
- 作者机构：
  
  1.北京师范大学
  2.中国原子能科学研究院
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Received：27 June 1984，
  
  Published：1986-03
- 稿件说明：
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Liyi Lu, Zhenghao Liu, Zhigang Tang, et al. The preparation of ²¹¹At-astatine labelled protein and peptides[J]. Nuclear techniques, 1986, 09(3): 46-47,60.
DOI：

Liyi Lu, Zhenghao Liu, Zhigang Tang, et al. The preparation of ²¹¹At-astatine labelled protein and peptides[J]. Nuclear techniques, 1986, 09(3): 46-47,60. DOI：

摘要

砹是重卤素，它是一个不存在稳定性同位素的放射性元素，半衰期7.2小时；它的α衰变分支比为42%，

电子俘获衰变分支比为58%；α粒子的平均能量为6.8MeV，在生物组织内的平均射程约为60µm。由于α粒子具有极强的电离效应，因而砹化的亲肿瘤化合物具有杀伤肿瘤细胞的潜在能力

［1

。从六十年代末就开始制备了多种

211

At标记的化合物

[1-3]

，1983年中国原子能科学研究院在我国首次制得了Na

211

At。我们采用固相酶

［9]

、H

和氯胺-T

［2

10]

等方法对BSA、IgG和甲硫－脑啡肽等进行了砹化标记。

Abstract

The preparation methods for the labelled proteins and peptides

with the radionuclide

211

are described.

The

211

At-labelled proteins and peptides

for example BSA

RbIgG and met-enkaphalin etc.

are obtained by several radioastatonation labelling methods

such as solid phase enzymes

and chloramine T etc.

among which the second is the best.

关键词

Keywords

references

А. Т. M. Vaughan et al . , Int. J. Appl. Radiat. Isotopes , 28 , 595 ( 1977 ).

C. Aaij et al . , ibid , 26 , 25 ( 1975 ).

G. W. M. Visser et al . , ibid , 32 , 913 ( 1981 ).

G. W. M. Visser et al . , J. Lab. Соmр. Radiopharm. , 18 , 127 ( 1981 ).

G. W. M. Visser et al . , ibid , 17 , 657 ( 1980 ).

Ian Ian , ibid , 19 , 1389 ( 1982 ).

Ian. Brown , Int. J. Appl. Radiat. Isotopes , 33 , 75 ( 1982 ).

G. W. M. Visser et al . , ibid , 32 , 905 ( 1981 ).

陆丽仪和田美荣，北京师范大学学报（自然科学版）， 1 , 77 ( 1984 ).

Vartan E. Ghajarossian et al . , Anal. Biochem. , 102 , 89 ( 1980 ).

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Biolabeling and application of the fac-[Μ（CO）₃]⁺(Μ=^188/186Re,⁹⁹Tc^m) compounds

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Related Institution

Shanghai Institute of Applied Physics, the Chinese Academy of Sciences

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The preparation of 211At-astatine labelled protein and peptides

DOI：

摘要

Abstract

关键词

Keywords

references

The preparation of ²¹¹At-astatine labelled protein and peptides