Synthesis of <sup>3</sup>H (<sup>2</sup>H)-labelled colchicine

Fenzhi Ling; Yuanlong Ye

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Synthesis of ³H (²H)-labelled colchicine

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- Synthesis of ³H (²H)-labelled colchicine
- Nuclear Techniques Vol. 07, Issue 2, (1984)
- 作者机构：
  
  中国科学院上海原子核研究所
- 作者简介：
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- Published：1984-04
- 稿件说明：
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Fenzhi Ling, Yuanlong Ye. Synthesis of ³H (²H)-labelled colchicine[J]. Nuclear techniques, 1984, 07(2): 48-51.
DOI：

Fenzhi Ling, Yuanlong Ye. Synthesis of ³H (²H)-labelled colchicine[J]. Nuclear techniques, 1984, 07(2): 48-51. DOI：

摘要

本工作介绍了秋水仙碱用0.2

HCl水解成秋水仙裂碱，然后以二氧六环为溶剂使秋水仙裂碱和氚(氘）水进行同位素交换，再用重氮甲烷的乙醚溶液甲基化。经过硅胶纸上行层析法分离纯化获得产品。经红外、紫外、质谱、硅胶纸层析鉴定，确定所得到的产品为秋水仙碱。氘标记物的氘化率为23%，氚标记物放射性比度为4.74Ci/mmol，放化纯度大于98%。

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P. A. Delwaid et al ., Ann. Belg. Ver. Stralingshescherming , 2 , 4 , 279 ( 1977 ).

J. Bryan , Ann. N. Y. Acad. Sci. , 253 , 247 ( 1975 ).

L. Wilson and M. Friedkin , Biochem. , 5 , 7 , 2463 ( 1966 ).

E. W. Taytor , J. Cell Biol. , 25 , 145 ( 1965 ).

R. F. Raffauf , J. Amer. Chem. Soc. , 75 , 2576 ( 1953 ).

R. M. Horowitz , J. Amer. Chem. Soc. , 74 , 587 ( 1952 ).

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Synthesis of 3H (2H)-labelled colchicine

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Synthesis of ³H (²H)-labelled colchicine