In vivo distribution and organ imaging of <sup>11</sup>C-benzoic acid and <sup>11</sup>C-propionic acid in animal

Qianmei Ji; Yongchuan Wang; Jiong Zhang; Xichang Shi; Yun Wang; Zhentang Zhou; Yifang Ye; Shengyang Chen; Caijie Gu; Fasheng Fan; Liufang Zhang; Haiqiu Bao; Weiyu He; Qixun Sun; Yongjian Li

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In vivo distribution and organ imaging of ¹¹C-benzoic acid and ¹¹C-propionic acid in animal

更新时间：2022-08-16

- In vivo distribution and organ imaging of ¹¹C-benzoic acid and ¹¹C-propionic acid in animal
- Nuclear Techniques Vol. 06, Issue 6, (1983)
- 作者机构：
  
  中国科学院上海原子核研究所
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Received：21 January 1983，
  
  Published：1983-12
- 稿件说明：
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Qianmei Ji, Yongchuan Wang, Jiong Zhang, et al. In vivo distribution and organ imaging of ¹¹C-benzoic acid and ¹¹C-propionic acid in animal[J]. Nuclear techniques, 1983, 06(6): 65-66,76.
DOI：

Qianmei Ji, Yongchuan Wang, Jiong Zhang, et al. In vivo distribution and organ imaging of ¹¹C-benzoic acid and ¹¹C-propionic acid in animal[J]. Nuclear techniques, 1983, 06(6): 65-66,76. DOI：

摘要

医用短寿命放射性核素

C是由加速器制备的，其原子核的物理性质适宜于人体显象。

C衰变发射的正电子经湮没产生一对方向相反的光子，由体外用符合测量定位准确，配合使用电子计算机和正电子断层照相机，可以得到对体内浓集部位的三维图象。

C-化合物参与体内某些代谢过程，则不仅可以做形态方面的定位观察，还可以获得有关整体条件下体内代谢过程的重要信息。苯甲酸在体内与甘氨酸结合生成马尿酸，迅速经肾曲小管排出，在此过程中将浓集于肾。心肌代谢中能量来源小部分由葡萄糖，大部分由脂肪酸类（油酸、软脂酸、硬脂酸）供给，因此各种脂肪酸进入血液后，将不同程度地浓集于心肌

。本文报导

C-苯甲酸和

C-丙酸在动物体内分布和由体外显象的试验结果。

Abstract

After

C-benzoic acid was intravenously injected to mice of ICR strain

the radioactivity was rapidly localized in kidney. The maximum uptake rate of kidney reached 52±5.7 D%/g. Observation of concentrating and elimination of

C-benzoic can be carried out within 15 minutes after intravenous injection to the rabbit under kinetic imaging. The propioic acid uptake rate of myocardium of mice was 12.5±4.2D%/g Either uptake ratio of heart to lung or that of heart to liver was around 1.9.

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references

M. B. Winsted et al . , J. Nucl. Med ., 14 , 747 （ 1973 ）.

E. J. Hoffman et al . , J. Nucl. Med ., 18 , 57 （ 1977 ）.

王耘等，原子能科学技术， 3 , 260 （ 1983 ）。

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In vivo distribution and organ imaging of 11C-benzoic acid and 11C-propionic acid in animal

DOI：

摘要

Abstract

关键词

Keywords

references

In vivo distribution and organ imaging of ¹¹C-benzoic acid and ¹¹C-propionic acid in animal