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中国科学院上海原子核研究所
Received:20 October 1931,
Published:1983-02
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Xialing Zhao, jingzhi Liu. Study on stability of L-[3,5-3H] tyrosine during storage[J]. Nuclear techniques, 1983, 06(1): 58-59,78.
L
-[3,5-
3
H]酪氨酸是研究蛋白质、肽类和甲状腺素等结构功能和代谢的重要示踪剂,在贮存中由于自身放出的低能
β
粒子,其能量将被自己或相邻的分子所吸收而有显著的自分解现象,致使
L
-[3,5-
3
H]酪氨酸会不断地产生放射性杂质。研究这种辐射自分解机理并设法控制它,已成为放射性标记化合物领域中一个新的方向
[1~3]
。有关
L
-[3,5-
3
H]酪氨酸的贮存与稳定性,未见有专题的研究报告。我们选用溶剂稀释来分散标记分子,添加自由基清除剂
(Free radical scavengers
)和降低温度等方法来探求
L
-[3,5-
3
H]酪氨酸在不同贮存条件下的自分解速率和途径。
L-[3
5-
3
H] tyrosine is an important radiochemical used in biochemical research. In this paper its stability in different storage conditions was described. The mechanism of self-decomposition was thus discussed.
G. Sheppard , Atomic Energy Review , 10 , 3 ( 1972 ).
E. A. Evans , Self-decomposition of radiochemicals, Review Booklet 16 . The Radiochemical Centre . Amersham , 1976 .
E. A. Evans , Tritium and its compounds ., 2nd ed . 1974 .
R. J. Bayly and E. A. Evans , Storage and stability of compounds labelled with radioisotopes., Review Booklet 7 . The Radiochemical Centre , Amersham 1968 .
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