Comparing the localizing characteristic of two bone imaging agents by autoradiography

Shoupeng Zhu; Guangren He

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Comparing the localizing characteristic of two bone imaging agents by autoradiography

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- Comparing the localizing characteristic of two bone imaging agents by autoradiography
- Nuclear Techniques Vol. 06, Issue 1, (1983)
- 作者机构：
  
  苏州医学院
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Received：24 April 1981，
  
  Published：1983-02
- 稿件说明：
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Shoupeng Zhu, Guangren He. Comparing the localizing characteristic of two bone imaging agents by autoradiography[J]. Nuclear techniques, 1983, 06(1): 56-57,78.
DOI：

Shoupeng Zhu, Guangren He. Comparing the localizing characteristic of two bone imaging agents by autoradiography[J]. Nuclear techniques, 1983, 06(1): 56-57,78. DOI：

摘要

应用各种亲骨性放射性核素进行骨病变的研究时，目前认为骨扫描具有较早的诊断价值

[1]

。对骨肿瘤的诊断定位，多使用

99m

Tc－焦磷酸盐和

99m

Tc－亚甲基二磷酸盐

[2]

。由于

99m

Tc的物理半衰期只有6.02小时，主要发射能量为140~142keV的低能γ射线，因而很适合于进行高速放射自显影的操作

［3

4］

。我们用放射自显影法对上述两种骨扫描剂进行了体内定位特性的对比研究。

Abstract

The autoradiographic study show that

99m

Tc-PYP was retained more than

99m

Tc-MDP in the blood stream. This was attributed to the rapid diffusion of the

99m

Tc-PYP into the circulating blood cell. The autoradiography of bone marrow smear shew that

99m

Tc-PYP localized predominately in the blast cell and freezing microautoradiography demonstrated that

99m

Tc-MDP deposited more in bone tissue than

99m

Tc-PYP. All of these might explain why

99m

Tc-MDP could produced good image shortly after administration.

关键词

Keywords

references

G. L. Schall , J. Surg. Oncol ., 3 , 673 ( 1971 ).

T. G. Rudd , J. Nucl. Med ., 18 , 872 ( 1977 ).

朱寿彭和江骥，中国药理学报， 2 , 1 , 64 （ 1981 ）.

朱寿彭，中国药理学报， 2 , 3 , 197 （ 1981 ）.

朱寿彭和江骥，放射医学与防护， 4 , 37 （ 1980 ）.

A. W. Rogers ed. , Techniques of autoradiography , 2nd ed . Amsterdam , Elsevier , 1973 , p. 44 .

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