The preparation of deuterium and tritium-labbelled 5-hydroxytryptamine creatinine sulphate

Nianbao Zhang; Rusong Wang

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The preparation of deuterium and tritium-labbelled 5-hydroxytryptamine creatinine sulphate

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- The preparation of deuterium and tritium-labbelled 5-hydroxytryptamine creatinine sulphate
- Nuclear Techniques Vol. 05, Issue 3, (1982)
- 作者机构：
  
  中国科学院上海原子核研究所
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Received：07 March 1981，
  
  Published：1982-06
- 稿件说明：
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Nianbao Zhang, Rusong Wang. The preparation of deuterium and tritium-labbelled 5-hydroxytryptamine creatinine sulphate[J]. Nuclear techniques, 1982, 05(3): 65-67.
DOI：

Nianbao Zhang, Rusong Wang. The preparation of deuterium and tritium-labbelled 5-hydroxytryptamine creatinine sulphate[J]. Nuclear techniques, 1982, 05(3): 65-67. DOI：

摘要

5-HTCS（I）是一种有效的血清血管收缩素，它具有改变神经细胞功能和产生血管收缩的作用。在生理生化和临床医学中，主要作为一种中枢神经介质或调节物来进行各种研究。为了进一步探讨它对生物体的内分泌和脑神经功能的作用机理，需要制备氘或氚标记5-HTCS。

Abstract

Deuterium or tritium-labelled 5-hydroxytryptamine creatinine sulphate was prepared by heating 5-hydroxytryptamine creatinine sulphate with deuterium or tritium gas in 4

HC1 and 5% PdO/BaSO

catalyst with an overall yield of 10~19%.

The mass spectrum data showed that with about 76% of deuterium was incorporated to 5-hydroxyptamine.

The specific radioactivity of the tritiated compound was 25.3Ci/m

with a radiochemical purity of more than 93%.

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references

K. E. Hamlin and F. E. Fisher , J. Amer. Chem, Soc. , 73 , 5007 ( 1951 ).

M. E. Speeter et al . , J. Amer. Chem. Soc . , 73 , 5514 ( 1951 ).

E. A. Evans , Tritium and Its Compounds , London , Butter, Worths , 1974 , p. 282 .

G. W. Kirby et al . , Chem. Commun . , 16 , 819 ( 1967 ).

J. W. Daly and B. Witkop , J. Amer. Chem. Soc. , 89 , 4 , 1032 ( 1967 ).

Olof Beck and Göran Sedvall , J. Label. Compounds , 11 , 1 , 57 ( 1975 ).

J. S. Fowler et al . , J. Label. Compounds and Radiophamaceuticals , 13 , 2 , 194 ( 1977 ).

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