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Shanghai Institute of Nuclear Research,Chinese Academy of Sciences
Received:25 December 1978,
Published:1980-08
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国忠 唐, 彦洪 梁, 林祥 殷. 氚标记保幼激素类似物—1-〔α-3H2-对乙基苯氧基〕-7-乙氧基-3,7-二甲基-2-辛烯的合成[J]. 核技术, 1980, 03(4): 55-57.
1-对乙基苯氧基-7-乙氧基-3
7-二甲基-2-辛烯(简称JHA-738)是我国首先用于家蚕增丝的一个有效的昆虫保幼激素类似物
[1]
。这类化合物的应用促进了我国养蚕事业的迅速发展。氚标记JHA-738主要用于研究其在昆虫体内的代谢、增丝机制及其残留动态,为其使用提供科学依据。
1-[α-
3
H
2
-p-ethylphenoxy]-7-ethoxy-3
7-dimethyl-2-octene was synthesized by condensation of 7-ethoxy geronyl bromide and
3
H-ethylphenol. The former was prepared from geraniol as starting material through alko xymercuration demercuration and bromination
and the later was obtained by catalyzed tritium reduction of acetylphenol. The product had high specific activity and good radiochemical purity.
中国科学院上海有机化学研究所昆虫激素组 , 化学学报 , 33 , 2 , 133 ( 1975 ).
H. Kamimura et al ., J. Agr. Food Chem. , 20 , 439 ( 1972 ).
A. M. Ajami and D. N. Crouse , J. Label. Compound. , 11 , 117 ( 1975 ).
J. H. Babler , J. Org. Chem. , 41 , 1262 ( 1976 ).
H. A. Jones and W. Wood , Ind. Eng. Chem. , 34 , 488 ( 1942 ).
N. Wakbagashi , J. Med. Chem. , 12 , 191 ( 1969 ).
H. C. Brown and P. Geoghegan , J. Am. Chem. Soc. , 89 , 1522 ( 1967 ).
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