骨骼显象剂从七十年代起发展很快。

85

Sr、

67m

Sr、

18

F等核素的骨骼显象剂已为

99m

Tc核素螯合的无机磷及有机膦化合物所取代。三聚磷酸盐、多聚磷酸盐、焦磷酸盐、1-羟基-1

1二膦酸基乙烷二钠盐以及次甲基二膦酸（MDP）等放射性药物，在临床应用上均具有良好的性能。国外最近报导

99m

Tc-MDP较多，认为它具有亲骨专一性强、血液清除率快、显影清晰、毒性低、不被肝脏所摄取等优点。此外，它亦可作为急性心肌梗塞部位的显象剂。

99m

Tc labelled methylene diphosphonic acid (MDP)

a bone imaging agent

was prepared. After chromatographic examination of purity

it was evaluated on rabbits and subjected to clinical trials on 56 patients of different bone diseases

The localization of MDP in bone was found to be higher than other phosphorous compounds in form of polyphosphate or EHDP. It was also highly concentrated in primary and metastatic bone tumors and was proved to be a satisfactory bone imaging agent.