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氚气和溶液中有机分子之间的同位素交换被认为是在有催化剂存在下发生的一种新的交换法
[1]
。近来报导了采用铂黑、钯黑或者PdO/BaSO
4
等作为催化剂的交换反应,在这种类型的交换反应中,发现PdO/BaSO
4
是最有效的催化剂,所有容易标记的位置都在靠近高电子云密度中心附近。根据文献报导在嘌呤类化合物中,氚标记在嘌呤环的第八位碳原子上。
Tritiated adenosine-5-triphosphate was prepared by heterogeneous catalytical isotopic exchange in solution with tritium gas. The specific activity of product was 27 Ci/mmol with radiochemical purity over 95%.
E. A. Evans et al ., J. Label. Compounds. , 10 , 4 , 569 ( 1974 ).
K. E. Wilzbach , J. Amer, Chem. Soc. , 79 , 1013 ( 1957 ).
T. Weshi and T. Takhashi ., Bull. Chem. Soc. Japan , 35 , 1510 ( 1962 ).
O. Buchman et al ., J. Label. Compounds , 10 , 2 , 345 ( 1974 ).
I. Pri-Bar and O. Buchman , Chem. Commun. , 1631 ( 1970 ).
R. Kuhn and H. J. Hass , Angew. Chem. , 67 , 785 ( 1955 ).
E. A. Evans , Tritium and its Compounds ., Butter worths , London , 1974 , p. 310 .
O. Buchman et al ., J . Label. Compounds. , 14 , 1 , 155 ( 1978 ).
I. Pri-Bar and O. Buchman , Int. J . Appl. Radia. Isotop. , 27 , 53 ( 1976 ).
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